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Thank you to all of the members of the department, each of whom has helped me to some degree. Your daily example means a great deal. Scholarship, graciousness, patience and compassion are a few of the qualities with which you inspire us, the students. Thank you to Professor Schwartzmann for inviting me to the department and giving me the courage to apply. Thank you to Professor Donald Sheehy for helpful suggestions and exemplary teaching. Thank you to Professor Rajasekaran, especially for helping me with United Technologies. Thank you to Professor Huang for conversations about computational biology. Thank you to Professor Mandoiu for conversations about architectural support for computational biology. Thank you to Professor Peters for conversations about computation biology on IBM BlueGene, and knots in computational biology. Thank you to Professors Gokhale and Ammar for shared papers, support and kindness. Thank you to Professors Russell and Michel for inspirational research and teaching. Thank you to Rebecca Randazzo and Joy Billion for exemplary competence and unfailing assistance. Thank you to Professor McCartney for support, example, and astonishing patience. Thank you to Jack, \textit{semper providente prospectu}.